Hyperbaric Oxygen Treatment (HBOT) has gained recognition as an effective therapy for various approved indications. However, recent research and clinical experience have shed light on its potential in treating conditions beyond those explicitly approved by regulatory bodies. These off-label applications of HBOT have shown promising results in improving patient outcomes and expanding the scope of this therapeutic modality. In this article, we will explore the off-label use of HBOT and its effectiveness in treating a range of medical conditions.

HBOT, also known as hyperbaric therapy, involves the administration of 100% pure oxygen at pressures higher than atmospheric pressure within a hyperbaric chamber. The increased oxygen concentration and pressure promote the dissolution of oxygen in body fluids, leading to enhanced oxygen delivery to tissues and organs. This, in turn, stimulates healing processes, reduces inflammation, and supports overall tissue repair and recovery.

While HBOT has received regulatory approval for several indications, there are instances where it is used off-label to treat conditions not explicitly listed in the approved indications. Off-label use refers to the use of a treatment or medication for a condition not specifically approved by regulatory authorities. Physicians may consider off-label use when there is clinical evidence and empirical data suggesting potential benefits.